Health technology assessment : HTA
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Health Technol Assess · Jun 2019
Randomized Controlled Trial Multicenter Study Pragmatic Clinical TrialNocturnal temperature-controlled laminar airflow device for adults with severe allergic asthma: the LASER RCT.
Severe asthma exacerbations are costly to patients and the NHS, and occur frequently in severely allergic patients. ⋯ Within the limits of the data, no consistent benefits of the active device were demonstrated, and the differences observed were not sufficient to make the device cost-effective. The types of patients who may benefit from the TLA device, and the reasons for large reductions in exacerbation frequency in severe asthma trials, which also incorporate other methods of recording exacerbations, need to be explored.