Biochemical and biophysical research communications
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Biochem. Biophys. Res. Commun. · Dec 2009
ReviewTRESK channel as a potential target to treat T-cell mediated immune dysfunction.
In this review, we propose that TRESK background K(+) channel could serve as a potential therapeutic target for T-cell mediated immune dysfunction. TRESK has many immune function-related properties. TRESK is abundantly expressed in the thymus, the spleen, and human leukemic T-lymphocytes. ⋯ Calcineurin has been found to interact with TRESK via specific NFAT-like docking site. When the T-cell is activated, calcineurin can bind to the NFAT-docking site of TRESK. The activation of both TRESK and NFAT via Ca(2+)-calcineurin-NFAT/TRESK pathway could modulate the transcription of new genes in addition to regulating several aspects of T-cell function.