International journal of pharmaceutical compounding
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Domperidone is a prokinetic agent used as a second-line treatment option for gastroparesis in those unable to tolerate metoclopramide. Via inhibition of dopamine-2 receptors within the gastrointestinal tract and various parts of the central and peripheral nervous system, domperidone helps to facilitate peristalsis and gastric emptying. A major side effect of domperidone is prolactinemia, allowing it to be used off-label for the purpose of inducing lactation. ⋯ Food and Drug Administration approved due to various case reports and literature associating the risks of sudden cardiac death and ventricular arrhythmia with the use of domperidone. Despite the evidence against the use of domperidone, it is still being widely used in Canada and Europe for both gastroparesis and to induce milk let-down. This article is a literature review intending to assess the risks associated with the use of domperidone in gastroparesis and lactation.
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This article represents the third in a series of articles on tips and hints ofcompounding. In this issue, we will discuss some tips and hints for the compounding of ointments, creams, pastes, gels, and gel-creams. For clarification, a gel-cream is a cream in which the external aqueous phase has been thickened using a gelling agent; the advantage is a more stable cream.
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Pain is extremely common in the U. S. It is estimated that 116 million Americans suffer from chronic pain. ⋯ Most of the respondents felt that these compounds allowed them to reduce their narcotic prescriptions overall. In addition, the results demonstrated that the prescribers felt these compounds were safe for their patients. In this small survey of practicing prescribing providers regarding the use of topical compounds, we found that these medications were not only effective but also safe.