International journal of pharmaceutical compounding
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The risk of microbial contamination during sterile product preparation would be practically non-existent were people not involved in the preparatory process. This article discusses why people are the main source of microbial contamination and what safeguards need to be present to minimize this source.
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Equipment systems that enable compliance with stringent state and federal compounding requirements are a topic of increasing interest to U. S. pharmacists. ⋯ In this article, the reasons for and the process of selecting an aseptic vial processing line for use in 2 independent 503B compounding pharmacies are presented, the operation of our choice of equipment is described, and specifications for the components of that line are listed. In part 2 of this series, the success of our choice and its effect on sterile compounding in our facilities will be reported.
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Films, which are a dosage form designed to dissolve on contact with a wet surface within a very short time, are thin sheets placed in the oral cavity for dissolution and absorption of the active drug. This dosage form is gaining popularity because of its convenience. Discussed within this article are the applications, advantages/disadvantages, composition, preparation, physicochemical considerations, quality control, packaging/labeling/storage, stability, and formulation considerations as they relate to films. Also provided are example formulations for compounding.