Scandinavian cardiovascular journal : SCJ
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Scand. Cardiovasc. J. · Dec 2000
Randomized Controlled Trial Clinical TrialEffect of allopurinol on myocardial oxygen free radical production in coronary bypass surgery.
Allopurinol protects the heart from reperfusion injury. The aim of this study was to investigate myocardial free radical production during reperfusion with and without allopurinol treatment in coronary artery bypass grafting patients randomized into allopurinol (n = 14) or placebo (n = 13) groups. ⋯ All patients in both groups had an increasing tendency to free radical production during early reperfusion. Patients treated with allopurinol showed less myocardial production of free radicals, indicating that its protective effect may be due to its antioxidative properties.