Scandinavian cardiovascular journal : SCJ
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Scand. Cardiovasc. J. · Oct 2001
Randomized Controlled Trial Clinical TrialInsulin (GIK) improves central mixed and hepatic venous oxygenation in clinical cardiac surgery.
Insulin is a vasodilating agent and it was hypothesized that insulin (GIK) could improve systemic and regional oxygenation in cardiac surgery with cardiopulmonary bypass (CPB). Two questions were addressed: 1) Does insulin improve central mixed and hepatic venous oxygenation during CPB? and 2) Does this treatment reduce systemic levels of the proinflammatory mediators C3a and IL-6? ⋯ 1) GIK infusion improved central mixed and hepatic venous oxygenation in patients undergoing heart surgery. 2) During the conditions of this study, this had no effect on the proinflammatory mediators C3a and IL-6.
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Scand. Cardiovasc. J. · Oct 2001
Randomized Controlled Trial Clinical TrialEffects of MgSO4 and glucose, insulin and potassium (GIK) on atrial conduction during the first 12 hours after DC-conversion of chronic atrial fibrillation.
To investigate changes in atrial conduction induced by MgSO4 and glucose, insulin and potassium (GIK) during the first 12-h period of sinus rhythm after successful DC-conversion of chronic atrial fibrillation (CAF). ⋯ Bolus infusion of MgSO4 2 h after DC-conversion of CAF produced an intra-atrial conduction delay that could be reversed by adding a GIK infusion, in spite of a concomitant increase in serum Mg concentration. No recovery of the intra-atrial conduction delay, seen after DC-conversion of CAF, was observed in either of the two groups during the 12-h study period.