Scandinavian cardiovascular journal : SCJ
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Scand. Cardiovasc. J. · Mar 2002
Is there an association between release of protein S100B during cardiopulmonary bypass and memory disturbances?
The use of protein S100B as a marker of brain cell injury in conjunction with cardiopulmonary bypass (CPB) has recently been questioned. The present study investigates functional brain injury based on the relation between S100B and memory disturbances. ⋯ Only high levels of protein S100B found 7 h post CPB were associated with decline of explicit memory function, not the release seen during CPB. Thus, when using protein S100B, only values several hours remote from surgery should be used as a brain cell injury marker.