Scandinavian cardiovascular journal : SCJ
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Scand. Cardiovasc. J. · Oct 2004
Randomized Controlled Trial Clinical TrialIsoflurane produces only minor preconditioning in coronary artery bypass grafting.
To investigate whether administration of isoflurane prior to cardiopulmonary bypass (CPB) could partly account for the observed protection of the myocardial function and to decrease myocardial injury in patients undergoing coronary artery bypass grafting (CABG). ⋯ Administration of isoflurane prior to commencing CPB may bring an improvement in early hemodynamic performance after CABG operations.
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Scand. Cardiovasc. J. · Oct 2004
Randomized Controlled Trial Comparative Study Clinical TrialThe benefits of continuous ultrafiltration in pediatric cardiac surgery.
Systemic inflammatory response and capillary leak syndrome, caused by extracorporeal circulation, have negative effects on the function of vital organs during the postoperative period. Modified ultrafiltration (MUF) has been developed as an alternative method to reduce the detrimental effects of cardiopulmonary bypass. The aim of this prospective, randomized study is to analyze the effects of MUF in a pediatric population undergoing congenital cardiac surgery. ⋯ MUF decreases the duration of mechanical ventilatory support, the length of intensive care unit stay, the need for blood transfusion and improves postoperative hemodynamics. It is associated with increased levels of hemoglobin, hematocrit and platelets. We can conclude that MUF attenuates the inflammatory response by decreasing the levels of inflammatory mediators.