Scandinavian cardiovascular journal : SCJ
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Scand. Cardiovasc. J. · Dec 2012
Randomized Controlled TrialDiazoxide may protect endothelial glycocalyx integrity during coronary artery bypass grafting.
Plasma hyaluronan and syndecan-1 levels represent shedding of the endothelium glycocalyx during ischemia and edema. Diazoxide, a K(ATP)-channel opener, has been shown to decrease myocardial edema during coronary artery bypass grafting (CABG). We evaluated whether diazoxide exerts an impact on plasma hyaluronan and syndecan-1 levels during CABG. ⋯ Diazoxide may have an impact on levels of peripheral plasma hyaluronan and syndecan-1 after CABG, suggesting decreased shedding of the endothelial glycocalyx layer.