Scandinavian cardiovascular journal : SCJ
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Scand. Cardiovasc. J. · Aug 2014
Randomized Controlled Trial Comparative StudyConditioning techniques and ischemic reperfusion injury in relation to on-pump cardiac surgery.
The objective was to investigate the potential protective effects of two conditioning methods, on myocardial ischemic and reperfusion injury in relation to cardiac surgery. ⋯ We were in this prospective randomized proof-of-concept trial, unable to show distinct protective effects of the studied conditioning methods. However, this trial can hopefully contribute to generate a productive discussion concerning limitations and future use of cardiac conditioning as well as microdialysis technique.
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Scand. Cardiovasc. J. · Aug 2014
Prognosis and response to first-line single and combination therapy in pulmonary arterial hypertension.
To investigate survival, treatment escalation, effects of first-line single- and first-line combination therapy and prognostic markers in idiopathic- (IPAH), hereditary- (HPAH) and connective tissue disease-associated (CTD-PAH) pulmonary arterial hypertension (PAH). ⋯ We confirm improved survival with PAH-targeted therapies. Survival is still poor and early treatment escalation frequently needed. First-line combination therapy may more potently improve haemodynamics. MRAP/CI may represent a new prognostic marker in PAH.