Scandinavian cardiovascular journal : SCJ
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Scand. Cardiovasc. J. · Jun 2018
Review Case ReportsMechanisms of action and clinical use of specific reversal agents for non-vitamin K antagonist oral anticoagulants.
With a steadily growing number of patients with non-valvular atrial fibrillation, anticoagulation use increases. Anticoagulation therapy is associated with increased risk of serious bleeding and an increased complexity in management of patients in need for urgent surgery. We wanted to assess the magnitude of this challenge as well as review current and potential future clinical management strategies. ⋯ Amongst patients using anticoagulants, around 3.5%, could be in need of immediate restoration of hemostasis annually. The availability and use of specific reversal agents for NOACs could be crucial for the clinical outcomes.