Scandinavian cardiovascular journal : SCJ
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Scand. Cardiovasc. J. · Apr 2006
Randomized Controlled Trial Clinical TrialTranexamic acid reduces postoperative bleeding in off-pump coronary artery bypass grafting.
Tranexamic acid (TA) reduces blood loss in coronary artery surgery with cardiopulmonary bypass. The present prospective study was designed to investigate its hemostatic effect in off-pump coronary artery bypass (OPCAB). ⋯ The results indicated that tranexamic acid limits fibrinolysis and reduces blood loss after off-pump coronary artery bypass surgery.
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Scand. Cardiovasc. J. · Dec 2005
Randomized Controlled TrialLeukocyte depleting filter attenuates myocardial injury during elective coronary artery bypass surgery.
Ischemia-reperfusion injury secondary to leukocyte activation has been widely recognized as one of the most relevant mechanism leading to postoperative organ dysfunction occurring after a period of ischemia. The aim of the present study was to evaluate in a prospective, randomized study, the value of leukocyte depleting filter in patients undergoing elective coronary artery bypass surgery. ⋯ The results of this study suggest a myocardial protective effect of leukocyte filter in the setting of elective coronary artery bypass surgery.
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Scand. Cardiovasc. J. · Apr 2005
Randomized Controlled Trial Comparative Study Clinical TrialPeripheral blood monocyte activation during coronary artery bypass grafting with or without cardiopulmonary bypass.
The aim of this prospective, randomized study was to investigate the impact of coronary artery bypass grafting (CABG) on peripheral monocytes and to evaluate the additional effect of cardiopulmonary bypass (CPB). ⋯ It is concluded that the circulating monocyte population is activated during and as a consequence of CABG. There were few apparent additional effects of CPB found in this study. In this setting the inflammation caused by the surgery procedure per se probably surpasses the impact of the CPB on circulating blood monocytes.
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Scand. Cardiovasc. J. · Oct 2004
Randomized Controlled Trial Clinical TrialIsoflurane produces only minor preconditioning in coronary artery bypass grafting.
To investigate whether administration of isoflurane prior to cardiopulmonary bypass (CPB) could partly account for the observed protection of the myocardial function and to decrease myocardial injury in patients undergoing coronary artery bypass grafting (CABG). ⋯ Administration of isoflurane prior to commencing CPB may bring an improvement in early hemodynamic performance after CABG operations.
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Scand. Cardiovasc. J. · Oct 2004
Randomized Controlled Trial Comparative Study Clinical TrialThe benefits of continuous ultrafiltration in pediatric cardiac surgery.
Systemic inflammatory response and capillary leak syndrome, caused by extracorporeal circulation, have negative effects on the function of vital organs during the postoperative period. Modified ultrafiltration (MUF) has been developed as an alternative method to reduce the detrimental effects of cardiopulmonary bypass. The aim of this prospective, randomized study is to analyze the effects of MUF in a pediatric population undergoing congenital cardiac surgery. ⋯ MUF decreases the duration of mechanical ventilatory support, the length of intensive care unit stay, the need for blood transfusion and improves postoperative hemodynamics. It is associated with increased levels of hemoglobin, hematocrit and platelets. We can conclude that MUF attenuates the inflammatory response by decreasing the levels of inflammatory mediators.