Scandinavian cardiovascular journal : SCJ
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Scand. Cardiovasc. J. · Oct 2016
Randomized Controlled Trial Multicenter StudyComorbidity burden is not associated with higher mortality after out-of-hospital cardiac arrest.
We investigated whether comorbidity burden of comatose survivors of out-of-hospital cardiac arrest (OHCA) affects outcome and if comorbidity modifies the effect of target temperature management (TTM) on final outcome. ⋯ Comorbidity burden was associated with higher mortality following OHCA, but when adjusting for confounders, the influence was no longer significant. The association between mCI and mortality was not modified by TTM. Comorbidity burden is associated with lower rates of bystander cardiopulmonary resuscitation after OHCA.
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Scand. Cardiovasc. J. · Jun 2015
Randomized Controlled TrialRemote ischemic preconditioning and incidence of postoperative atrial fibrillation.
Although remote ischemic preconditioning (RIPC) has shown favorable effects on ischemia-reperfusion injury, much remains unknown of its mechanisms and clinical significance. We hypothesized that RIPC would reduce the incidence of postoperative atrial fibrillation (POAF) following coronary artery bypass graft (CABG) surgery. In addition, we investigated whether RIPC could induce alterations of circulating microRNA in blood plasma. ⋯ We did not observe a reduced incidence of POAF by RIPC before CABG surgery. Larger multi-center studies may be necessary to further clarify this issue.
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Scand. Cardiovasc. J. · Aug 2014
Randomized Controlled Trial Comparative StudyConditioning techniques and ischemic reperfusion injury in relation to on-pump cardiac surgery.
The objective was to investigate the potential protective effects of two conditioning methods, on myocardial ischemic and reperfusion injury in relation to cardiac surgery. ⋯ We were in this prospective randomized proof-of-concept trial, unable to show distinct protective effects of the studied conditioning methods. However, this trial can hopefully contribute to generate a productive discussion concerning limitations and future use of cardiac conditioning as well as microdialysis technique.
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Scand. Cardiovasc. J. · Dec 2013
Randomized Controlled Trial Comparative StudyRandomized trial of HTK versus warm blood cardioplegia for right ventricular protection in mitral surgery.
To clarify the reliability of the one-shot histidine-tryptophane-ketoglutarate (HTK) cardioplegia for right ventricular (RV) myocardial protection during mitral surgery, in patients with or without pre-operative RV dysfunction. ⋯ The one shot HTK solution offers inferior RV protection compared with WBC, mainly in patients with depressed pre-operative RV function. When adopting HTK cardioplegia the addition of topical cooling is strongly advised.
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Scand. Cardiovasc. J. · Dec 2013
Randomized Controlled TrialRetransfusion of cardiotomy suction blood impairs haemostasis: ex vivo and in vivo studies.
Cardiotomy suction blood in volumes corresponding to 10-20% of the systemic blood volume is retransfused during cardiopulmonary bypass. We hypothesized that retransfusion of unwashed cardiotomy suction blood influences coagulation and platelet function. ⋯ The ex vivo results suggest that addition of unwashed cardiotomy suction blood in clinically relevant volumes impairs systemic haemostasis. Retransfusion of smaller volumes in vivo has no or limited impact. Avoiding retransfusion of larger amounts of unwashed cardiotomy suction may improve postoperative haemostasis.