Scandinavian cardiovascular journal : SCJ
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Scand. Cardiovasc. J. · Mar 2004
Randomized Controlled Trial Comparative Study Clinical TrialOff-pump CABG reduces complement activation but does not significantly affect peripheral endothelial function: a prospective randomized study.
Cardiac surgery initiates a systemic inflammatory response, which may affect endothelial function. The aim of this study was to investigate if off-pump CABG (OPCAB) reduces the postoperative inflammatory response and affects endothelial function less than conventional on-pump CABG. ⋯ OPCAB reduces complement activation compared with on-pump CABG but does not significantly affect TNF-alpha and IL-8 release or endothelial function.
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Scand. Cardiovasc. J. · Aug 2002
Randomized Controlled Trial Clinical TrialUse of heparin-bonded circuits in cardiopulmonary bypass improves clinical outcome.
The use of heparin-coated surfaces in cardiopulmonary bypass has been shown to decrease the inflammatory response imposed by the contact between blood and artificial surfaces. One would expect this reaction to improve clinical outcome. However, this has been difficult to verify. This investigation is based on an aggregation of two randomized studies from our institution and highlights possible effects of heparin coating on a number of clinically oriented parameters. ⋯ Based on several indicators, the use of heparin coating in cardiopulmonary bypass is associated with improved clinical results.
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Scand. Cardiovasc. J. · Oct 2001
Randomized Controlled Trial Clinical TrialInsulin (GIK) improves central mixed and hepatic venous oxygenation in clinical cardiac surgery.
Insulin is a vasodilating agent and it was hypothesized that insulin (GIK) could improve systemic and regional oxygenation in cardiac surgery with cardiopulmonary bypass (CPB). Two questions were addressed: 1) Does insulin improve central mixed and hepatic venous oxygenation during CPB? and 2) Does this treatment reduce systemic levels of the proinflammatory mediators C3a and IL-6? ⋯ 1) GIK infusion improved central mixed and hepatic venous oxygenation in patients undergoing heart surgery. 2) During the conditions of this study, this had no effect on the proinflammatory mediators C3a and IL-6.
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Scand. Cardiovasc. J. · Oct 2001
Randomized Controlled Trial Clinical TrialEffects of MgSO4 and glucose, insulin and potassium (GIK) on atrial conduction during the first 12 hours after DC-conversion of chronic atrial fibrillation.
To investigate changes in atrial conduction induced by MgSO4 and glucose, insulin and potassium (GIK) during the first 12-h period of sinus rhythm after successful DC-conversion of chronic atrial fibrillation (CAF). ⋯ Bolus infusion of MgSO4 2 h after DC-conversion of CAF produced an intra-atrial conduction delay that could be reversed by adding a GIK infusion, in spite of a concomitant increase in serum Mg concentration. No recovery of the intra-atrial conduction delay, seen after DC-conversion of CAF, was observed in either of the two groups during the 12-h study period.
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Scand. Cardiovasc. J. · Dec 2000
Randomized Controlled Trial Clinical TrialEffect of allopurinol on myocardial oxygen free radical production in coronary bypass surgery.
Allopurinol protects the heart from reperfusion injury. The aim of this study was to investigate myocardial free radical production during reperfusion with and without allopurinol treatment in coronary artery bypass grafting patients randomized into allopurinol (n = 14) or placebo (n = 13) groups. ⋯ All patients in both groups had an increasing tendency to free radical production during early reperfusion. Patients treated with allopurinol showed less myocardial production of free radicals, indicating that its protective effect may be due to its antioxidative properties.