CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
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Stroke is a major cause of morbidity and mortality in an aging population. The current understanding of the pathophysiology of atherosclerotic diseases, the most common cause of stroke, and the evidence for existing therapeutic interventions for the prevention of stroke are presented. Specifically, we review the evidence for antiplatelet agents, anticoagulants, antihypertensive medications, lipid-lowering agents and carotid endarterectomy for stroke prevention.
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Review Case Reports
The patient with transient cerebral ischemia: a golden opportunity for stroke prevention.
Transient ischemic attack (TIA) provides a golden opportunity for stroke prevention. TIA should be treated as a medical emergency with prompt investigations to determine the mechanism of ischemia and subsequent preventive therapy. ⋯ The risk is time-dependent with 50% of the risk accruing in the first 48 hours. In this review, we describe the diagnosis and management of TIA, introduce new concepts in TIA and suggest that all patients with significant TIA should undergo rapid investigation and management to prevent stroke.
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Review Practice Guideline Guideline
Clinical practice guidelines for the care and treatment of breast cancer: 15. Treatment for women with stage III or locally advanced breast cancer.
To define the optimal treatment for women with stage III or locally advanced breast cancer (LABC). ⋯ The Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer was convened by Health Canada. Completion date: December 2003.
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Review Practice Guideline Guideline
Clinical practice guidelines for the care and treatment of breast cancer: 15. Treatment for women with stage III or locally advanced breast cancer.
To define the optimal treatment for women with stage III or locally advanced breast cancer (LABC). ⋯ The Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer was convened by Health Canada. Completion date: December 2003.