CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
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Meta Analysis
Efficacy and safety of insulin analogues for the management of diabetes mellitus: a meta-analysis.
Although insulin analogues are commonly prescribed for the management of diabetes mellitus, there is uncertainty regarding their optimal use. We conducted meta-analyses to compare the outcomes of insulin analogues with conventional insulins in the treatment of type 1, type 2 and gestational diabetes. ⋯ Rapid-and long-acting insulin analogues offer little benefit relative to conventional insulins in terms of glycemic control or reduced hypoglycemia. Long-term, high-quality studies are needed to determine whether insulin analogues reduce the risk of long-term complications of diabetes.