CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
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Multicenter Study
Risk of hypoglycemia following intensification of metformin treatment with insulin versus sulfonylurea.
Hypoglycemia remains a common life-threatening event associated with diabetes treatment. We compared the risk of first or recurrent hypoglycemia event among metformin initiators who intensified treatment with insulin versus sulfonylurea. ⋯ Among patients using metformin who could use either insulin or sulfonylurea, the addition of insulin was associated with a higher risk of hypoglycemia than the addition of sulfonylurea. This finding should be considered by patients and clinicians when discussing the risks and benefits of adding insulin versus a sulfonylurea.