British journal of anaesthesia
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Comparative Study
Effect of lithium and rubidium on the sleeping time caused by various intravenous anaesthetics in the mouse.
The effects of acute and long-term lithium (LiCl) and rubidium chloride (RbCl) treatments on the sleeping time caused by intravenous thipentone, methohexitone, ketamine, propanidid. Althesin and diazepam were studied in white mice. ⋯ Both LiCl and RbCl, given acutely, enhanced the sleeping time caused by diazepam. The rectal temperatures were lower in the LiCl-treated mice than in the control and RbCl-treated mice.
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Pulmonary gas distribution, functional residual capacity (FRC), closing capacity (CC), arterial oxygen tension (PaO2) and alveolar-arterial oxygen tension gradient (PAO2-PAO2) were measured in seven subjects before and after the induction of extradural analgesia for routine surgery. It was found that pulmonary gas distribution was within normal limits throughout the study, although there were two patients in whom airway closure occurred consistently within the tidal volume. ⋯ CC and FRC were substantially unchanged by the induction of extradural analgesia. Changes in (PAO2-PaO2) and PaO2 were usually not large, and are apparently related to factors other than changes in lung geometry.