British journal of anaesthesia
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Comparative Study
Respiratory effects of a new opiate analgesic, R 39209, in the rabbit: comparison with fentanyl.
The respiratory effects of R 39209, a new short-acting analgesic, were studied and compared with those of fentanyl, in the rabbit. Minute volume, respiratory frequency and pH, PCO2 and standard bicarbonate of arterialized venous blood were measured. ⋯ Fentanyl was between 2 and 3.5 times more potent than R 39209. Repeated doses of R 39209 produced reproducible peak effects even when only 10 min was allowed between administrations.
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The criteria for an oxygen fail-safe device are designed to prevent a hypoxic gas mixture being administered to the patient should the oxygen supply fail, be disconnected, or be turned off. A fail-safe device which fulfils these criteria is described.