British journal of anaesthesia
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Randomized Controlled Trial Clinical Trial
Use of di-isopropyl phenol as main agent for short procedures.
The use of di-isopropyl phenol (Diprivan) for induction of anaesthesia was assessed in doses ranging from 1 to 3 mg kg-1. With less than 1.75mg kg-1 not all patients were anaesthetized; 2.0 mg kg-1 appeared to be a satisfactory induction dose. Involuntary muscle movement, cough and hiccup at induction were rare with any dose studied. ⋯ Recovery was rapid, and characterized by lack of emetic sequelae. Di-isopropyl phenol 1.5 - 2.0 mg kg-1 given rapidly during reactive hyperaemia can produce anaesthesia in one arm-brain circulation time. A reaction involving flush, hypotension, cough, laryngospasm and bronchospasm occurred in one patient receiving 2.5 mg kg-1 given over 20 s.
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Randomized Controlled Trial Comparative Study Clinical Trial
Effect of high-dose fentanyl anaesthesia on the metabolic and endocrine response to cardiac surgery.
The effect of high-dose fentanyl anaesthesia (75 micrograms kg-1) on the metabolic and endocrine responses to cardiac surgery was compared with results obtained in similar patients who had received incremental doses of papaveretum. High-dose fentanyl anaesthesia prevented the increases in blood glucose, plasma cortisol and plasma growth hormone concentrations found before cardiopulmonary bypass, but during cardiopulmonary bypass was only effective in decreasing the hyperglycaemia. The continued administration of fentanyl following operation failed to suppress the hormonal and metabolic changes so that the total urinary excretion during the first 5 days after surgery was similar in both groups of patients. High-dose fentanyl anaesthesia was associated with only transient metabolic benefits confined to the period during operation.