British journal of anaesthesia
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Randomized Controlled Trial Clinical Trial
Changes in fetal TCPO2 values occurring during labour in association with lumbar extradural analgesia.
Forty-six of 64 high risk labours were managed with continuous lumbar extradural analgesia. Fetal heart rate (FHR) and continuous transcutaneous PO2 (tcPO2) measurements were made in the 64 patients. ⋯ These effects and the changes in FHR were not seen in the 18 mothers not receiving extradural analgesia. The supine position was associated with slightly smaller fetal tcPO2 values than the preferred lateral positions, with a significant worsening of the fetal tcPO2 values after induction of the extradural block although, overall, extradural analgesia neither improved nor impaired the fetal tcPO2.
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Randomized Controlled Trial Comparative Study Clinical Trial
Dose-response relation for atracurium, ORG NC 45 and pancuronium.
The potencies of atracurium, Org NC 45 and pancuronium were determined using cumulative dose-response curves. The effective doses producing 95% twitch depression were 279 microgram kg-1, 56 microgram kg-1 and 64 microgram kg-1 respectively, the relative potency being 1:5.0:4.3. ⋯ The three drugs provided equal and generally good intubating conditions at approximately 95% twitch depression. Greater arterial pressure and heart rate were seen with pancuronium than with atracurium and Org NC 45.