British journal of anaesthesia
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Randomized Controlled Trial Comparative Study Clinical Trial
Effects on coagulation of intravenous crystalloid or colloid in patients undergoing peripheral vascular surgery.
This study investigated whether haemodilution-enhanced coagulation can be demonstrated under regional anaesthesia, whether this occurs before surgery, and whether the fluid used influences the effect. ⋯ This study confirms that the enhanced perioperative coagulation mechanism is related to dilution, rather than surgery, and is triggered by rapid crystalloid haemodilution. Consideration should be given to the use of colloid rather than crystalloid solutions for rapid fluid loading in vasculopathic patients undergoing surgery.
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Randomized Controlled Trial Clinical Trial
Optimal rocuronium dose for intubation during inhalation induction with sevoflurane in children.
We studied 120 children aged 2-7 yr in a prospective, randomized, assessor-blinded fashion to define the optimal rocuronium dose which provides a 95% probability of acceptable intubation conditions (ED95TI) during inhalation induction with sevoflurane. ⋯ During inhalation induction with 8% sevoflurane in 60% nitrous oxide, rocuronium 0.29 mg kg-1 (ED95) optimizes intubation conditions for surgery of short duration.
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Randomized Controlled Trial Clinical Trial
Propofol attenuates myocardial lipid peroxidation during coronary artery bypass grafting surgery.
Propofol can scavenge free radicals because it has a chemical structure similar to antioxidants. ⋯ In clinical doses, propofol strongly attenuates lipid peroxidation during CABG surgery.
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Randomized Controlled Trial Clinical Trial
Plasma concentration of ropivacaine after intercostal blocks for video-assisted thoracic surgery.
Absorption of local anaesthetics following intercostal blocks is rapid. Therefore, plasma concentrations of ropivacaine during intercostal blocks with ropivacaine 2, 5, 7.5 and 10 mg ml-1 (ropivacaine 5 ml injected into each of four intercostal spaces) in patients undergoing video-assisted thoracic surgery were determined. ⋯ After intercostal blocks the absorption of ropivacaine is rapid compared with other techniques for regional anaesthesia and results in relatively high venous and arterial plasma concentrations, especially if a dose of 100 mg or more is used.