British journal of anaesthesia
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The analgesic effects of morphine are delayed relative to its concentration in blood. The rate of equilibration of morphine between blood and brain may contribute to this delay, but the kinetics of this process have not been modelled. This was determined in conscious instrumented sheep. The lung kinetics of morphine were also determined given their importance in defining systemic kinetics after i.v. bolus administration. ⋯ The cerebral equilibration of morphine was relatively slow, and was characterized by significant membrane limitation.
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Randomized Controlled Trial Clinical Trial
Effects of dexamethasone on clinical course, C-reactive protein, S100B protein and von Willebrand factor antigen after paediatric cardiac surgery.
Anti-inflammatory treatment with glucocorticoids during cardiopulmonary bypass can reduce inflammatory mediator release, but the effects of glucocorticoid on outcome are controversial. ⋯ Administration of dexamethasone before cardiopulmonary bypass for paediatric cardiac surgery decreased the inflammatory response, but did not affect the immediate features after surgery or changes in vWf:Ag or S100B.
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Randomized Controlled Trial Clinical Trial
Analgesic effects of parecoxib following total abdominal hysterectomy.
Forty-eight ASA I-II patients undergoing total abdominal hysterectomy (TAH) were studied in a double blind, randomized placebo controlled trial of parecoxib for postoperative analgesia. ⋯ Parecoxib 40 mg i.v. may be recommended in patients having TAH as it provides morphine-sparing analgesia.
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Randomized Controlled Trial Clinical Trial
Sedation caused by clonidine in patients with spinal cord injury.
In patients with spinal cord injury, cephalad spread of intrathecal (i.t.) medication could be delayed. ⋯ A systemic effect is likely to be the main reason for sedation.