British journal of anaesthesia
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Randomized Controlled Trial
Central nervous system penetration of oxycodone after intravenous and epidural administration.
Despite being increasingly used for pain management, only two studies, with controversial results, have evaluated the epidural use of oxycodone. ⋯ EudraCT reference number: 2011-000125-76.
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Clinical Trial
Gas chromatograph-surface acoustic wave for quick real-time assessment of blood/exhaled gas ratio of propofol in humans.
Although pilot studies have reported that exhaled propofol concentrations can reflect intraoperative plasma propofol concentrations in an individual, the blood/exhaled partial pressure ratio RBE varies between patients, and the relevant factors have not yet been clearly addressed. No efficient method has been reported for the quick evaluation of RBE and its association with inter-individual variables. ⋯ ChiCTR-ONC-13003291.
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Randomized Controlled Trial
Clinical decision-making augmented by simulation training: neural correlates demonstrated by functional imaging: a pilot study.
Investigation of the neuroanatomical basis of clinical decision-making, and whether this differs when students are trained via online training or simulation training, could provide valuable insight into the means by which simulation training might be beneficial. ⋯ The activation areas seen could indicate increased stress when answering clinical questions compared with general non-clinical questions, and in the online group when answering action-based clinical questions. These findings suggest simulation training attenuates neural responses related to stress when making clinical decisions.
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Randomized Controlled Trial
Does circumferential spread of local anaesthetic improve the success of peripheral nerve block?
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Randomized Controlled Trial
Transcutaneous electric acupoint stimulation reduces intra-operative remifentanil consumption and alleviates postoperative side-effects in patients undergoing sinusotomy: a prospective, randomized, placebo-controlled trial.
Although opioids are widely used as analgesics in general anaesthesia, they have unpleasant side-effects and can delay postoperative recovery. Acupuncture and related techniques are effective for acute and chronic pain, and reduces some side-effects. We assessed the effect of transcutaneous electric acupoint stimulation (TEAS) on intra-operative remifentanil consumption and the incidences of anaesthesia-related side-effects. ⋯ The trial was registered at clinicaltrials.gov (NCT01700855).