British journal of anaesthesia

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• Br J Anaesth · Apr 2014

  Comment Letter

  'State-of-the-art general anaesthesia' compared with 'standard-of-care spinal anaesthesia' for unilateral knee arthroplasty: ethics and philosophical considerations.

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• Br J Anaesth · Apr 2014

  Comment Letter

  Catheter-over-needle method reduces risk of perineural catheter dislocation.

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• Br J Anaesth · Apr 2014

  Comment Letter

  Factors affecting perineural catheter dislocation rates.

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• Br J Anaesth · Mar 2014

  Randomized Controlled Trial

  β2-Adrenoceptor gene variants affect vasopressor requirements in patients after thoracic epidural anaesthesia.

  While the β2-adrenoceptor pathway is essential for cardiovascular regulation, the impact of ADRB2 gene variations on circulatory responses is unclear, possibly due to neural compensatory mechanisms. We tested the hypotheses that (i) sympathetic block by thoracic epidural anaesthesia (TEA) unmasks the influence on arterial pressure of genetic variations and (ii) vasopressor requirements during TEA depend on ADRB2 gene variation. ⋯ The ADRB2 Glu27 allele is an independent predictor of arterial hypotension and vasopressor requirements after TEA. Neural block can unmask genetic influences on neurohumoral regulation. Clinical trial registration DRKS00005260.

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• Br J Anaesth · Mar 2014

  Comment Letter

  Sedation: it is better to be safe than sorry.

  no abstract available

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