British journal of anaesthesia
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This article was published by mistake in the June issue of BJA due to an administrative error. It was supposed to go into this special issue on Memory and Awareness in Anaesthesia. The article can be accessed free of charge at the following link: http://bja.oxfordjournals.org/lookup/doi/10.1093/bja/aev095 The Publisher apologizes for the error.
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T-type Ca(2+) channels (TCC) are important for pain transmission, especially the Ca(V)3.2 subtype. In this study, we examined the effects of intrathecal TCC blockers in the L5/6 spinal nerve ligation pain rat model. ⋯ In this study, we demonstrated that intrathecal TCC blockers attenuate the development of nerve injury-induced mechanical allodynia and thermal hyperalgesia. Our data suggest that continuous intrathecal infusion of TCC or Ca(V)3.2 blockers may be a promising alternative for the management of nerve injury-induced pain.