British journal of anaesthesia
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Pholcodine consumption greatly increases the risk of NMBD anaphylaxis (OR 14.0).
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Randomized Controlled Trial Comparative Study
Lung recruitment in the prone position after cardiac surgery: a randomised controlled study.
Atelectasis after cardiac surgery is common and promotes ventilation/perfusion mismatch, infection, and delayed discharge from critical care. Recruitment manoeuvres are often performed to reduce atelectasis. In severe respiratory failure, recruitment manoeuvres in the prone position may increase oxygenation, survival, or both. We compared the effects of recruitment manoeuvres in the prone vs supine position on lung aeration and oxygenation in cardiac surgical patients. ⋯ NCT03009331.
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Randomized Controlled Trial
Opioids and premature biochemical recurrence of prostate cancer: a randomised prospective clinical trial.
Prostate cancer is one of the most prevalent neoplasms in male patients, and surgery is the main treatment. Opioids can have immune modulating effects, but their relation to cancer recurrence is unclear. We evaluated whether opioids used during prostatectomy can affect biochemical recurrence-free survival. ⋯ NCT03212456.
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Randomized Controlled Trial Comparative Study
Determination of equi-analgesic doses of inhaled methoxyflurane versus intravenous fentanyl using the cold pressor test in volunteers: a randomised, double-blinded, placebo-controlled crossover study.
Inhaled methoxyflurane for acute pain relief has demonstrated an analgesic effect superior to placebo. Data comparing methoxyflurane to an opioid are needed. The aim of this study was to determine the equi-analgesic doses of inhaled methoxyflurane vs i.v. fentanyl. Both drugs have an onset within minutes and an analgesic effect of 20-30 min. ⋯ NCT03894800.