British journal of anaesthesia
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Review Meta Analysis
Effects of general anaesthesia during pregnancy on neurocognitive development of the fetus: a systematic review and meta-analysis.
The US Food and Drug Administration warned that exposure of pregnant women to general anaesthetics may impair fetal brain development. This review systematically evaluates the evidence underlying this warning. ⋯ CRD42018115194.
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Letter Randomized Controlled Trial
Microcirculatory effects of landiolol: a double-blind, randomised, controlled study after cardiac surgery.
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Both animal and retrospective human studies have linked extended and repeated general anaesthesia during early development with cognitive and behavioural deficits later in life. However, the neuronal circuit mechanisms underlying this anaesthesia-induced behavioural impairment are poorly understood. ⋯ Repeated exposure of neonatal mice to propofol anaesthesia during early development causes cortical circuit dysfunction and behavioural impairments in later life. Potentiation of neuronal activity during recovery from anaesthesia reduces these adverse effects of early-life anaesthesia.