International journal of clinical practice
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Int. J. Clin. Pract. · Aug 2008
Randomized Controlled Trial Multicenter StudyPatient assessment of a novel therapeutic approach for the treatment of severe, chronic pain.
Opioid-induced constipation can have a major negative impact on patients' quality of life. This randomised clinical trial evaluated patient assessment of the efficacy and tolerability of oral prolonged-release (PR) oxycodone when co-administered with oral naloxone PR. ⋯ The co-administration of oral naloxone PR with oxycodone PR improves patient assessment of analgesic opioid therapy for severe chronic pain, in terms of both efficacy and tolerability.