International journal of clinical practice
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Int. J. Clin. Pract. · Jan 2010
Randomized Controlled Trial Multicenter StudyRapid relief of acute sore throat with AMC/DCBA throat lozenges: randomised controlled trial.
As antibiotics are generally not recommended for the treatment of acute sore throat, the availability of clinically efficacious, over-the-counter (OTC) treatment alternatives is becoming increasingly important. This study was designed to determine the analgesic properties of amylmetacresol and 2,4-dichlorobenzyl alcohol (AMC/DCBA) throat lozenges (Strepsils) in the relief of acute sore throat caused by upper respiratory tract infections. ⋯ Amylmetacresol/DCBA throat lozenges provide rapid analgesic effects that last for 2 h, providing ongoing relief long after the lozenge has dissolved. The superior analgesic effects and improvements in functional impairment scores observed with AMC/DCBA throat lozenges translate into pain relief benefits that are clinically meaningful and are thus a suitable OTC treatment option for patients in the self-management of acute sore throat.
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Int. J. Clin. Pract. · Jan 2010
Randomized Controlled Trial Multicenter StudyAdding liraglutide to oral antidiabetic drug therapy: onset of treatment effects over time.
To investigate the onset of treatment effects over time observed for liraglutide in combination with oral antidiabetic drugs (OADs). ⋯ Liraglutide treatment combined with OADs led to rapid improvements in FPG and SBP. Early reductions in HbA(1c) and body weight were also observed. Adding liraglutide to OADs early on may therefore be a good treatment option for patients with type 2 diabetes.