International journal of clinical practice
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Int. J. Clin. Pract. · Jun 2012
Review Meta AnalysisEfficacy of folic acid supplementation in stroke prevention: new insight from a meta-analysis.
There are growing data and a continuing controversy over the efficacy of folic acid supplementation in stroke prevention. We conducted a meta-analysis based on relevant, up-to-date published randomised trials to further examine this issue. ⋯ Our analysis indicated that folic acid supplementation is effective in stroke prevention in populations with no or partial folic acid fortification. In addition, a greater beneficial effect was observed among trials with a lower percent use of statins. Our findings underscore the importance of identifying target populations that can particularly benefit from folic acid therapy.