International journal of clinical practice
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Int. J. Clin. Pract. · Mar 2021
Impact of the multidisciplinary antimicrobial stewardship team intervention focusing on carbapenem de-escalation: a single-center and interrupted time series analysis.
As a result of the constant increase in carbapenem resistance amongst gram-negative bacteria in several countries, the inappropriate use of carbapenems must be reduced. Antimicrobial stewardship programmes (ASPs) aim to improve carbapenem usage by implementing interventions, including the promotion of the de-escalation (DE) strategy. Thus, this study aimed to evaluate the impact of this strategy on carbapenem use based on a clear definition of DE. ⋯ The PPRF strategy implemented by the AST could improve the carbapenem usage by increasing the DE rate of carbapenem.
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Int. J. Clin. Pract. · Mar 2021
Estimation of folic acid/micro nutrients levels; does it reflect sperm parameters.
To study the impact of vitamin B12, folic acid (FA) and methylmalonic acid (MMA) on sperm parameters; count, motility and morphology leading to male fertility. ⋯ All the studied micronutrients; Vitamin B12, FA and MMA had a positive effect on sperm parameters; count, motility and morphology and the associated reproductive hormones which explains their role on reproductive functions required to acquire fertility.
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Int. J. Clin. Pract. · Mar 2021
Comparing re-hospitalization rates in a real-world naturalistic 24- month follow-up of psychotic patients with different treatment strategies: oral versus LAI antipsychotics.
Non-adherence to antipsychotic treatment is a major issue in the management of severe psychiatric disorders, because it is usually related to future relapses and re-hospitalisations. Long-Acting-Injection (LAI) antipsychotics can be useful to increase treatment adherence in these patients. The aim of the present study was to compare the re-hospitalisation rates of psychotic patients discharged from a psychiatric ward and then, divided into three groups upon the treatment received: LAI antipsychotic, oral antipsychotic at home or oral antipsychotic administered daily by psychiatric nurse staff as patients lived in a long-term care facility. ⋯ This study highlights the impact of LAI antipsychotics in preventing re-hospitalisation in severe psychotic patients at high risk in a naturalistic setting. The benefits appear relevant also with respect to a controlled long-term oral antipsychotic treatment, however, further studies are needed to develop more tailored intervention strategies in such complex psychiatric population.
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Int. J. Clin. Pract. · Mar 2021
The Relationship Between Non- Segmental Vitiligo, HLA Genotype and Oxidative Stress.
Vitiligo is an autoimmune disease characterised by acquired loss of melanocytes. Although the pathogenesis of vitiligo remains unknown, oxidative stress and autoimmune dysregulations are considered to play a role. ⋯ Our study showed that HLA-A*02 increases, HLA-A*11 and HLA-DRB1*01 decreases vitiligo susceptibility in Turkish patients as well as a possible relationship between HLA and TAC.
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Int. J. Clin. Pract. · Mar 2021
Continuous Focus on COVID-19 Epidemic: Changes in China's Clinical Guidance.
The epidemic of coronavirus disease 2019 (COVID-19) is spreading across the world. As the first country who suffered from the outbreak, China has been taking strict and effective measures to contain the epidemic and treat the disease under the instruction of updating guidance. ⋯ We have made a summary of the changes and updates in China's clinical guidance for COVID-19, which mirrors the deepening understanding of the disease over the course of fighting it, hoping to help clinicians worldwide.