International journal of clinical practice
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Int. J. Clin. Pract. · Mar 2021
Multicenter StudyThe Effect of Body Mass Index on Oncological and Surgical Outcomes in Patients Undergoing Radical Cystectomy for Bladder Cancer: A Multicenter Study of the Association of Urooncology, Turkey.
We aimed to evaluate the effect of body mass index (BMI) on oncological and surgical outcomes in patients who underwent radical cystectomy (RC) for bladder cancer (BC). ⋯ Our study showed that although major complications are more common in obese patients, the increase in BMI does not reveal a significant negative effect on OS, CSS, RFS and MFS.
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Int. J. Clin. Pract. · Mar 2021
Multicenter Study Observational StudyAtrial fibrillation pattern, left atrial diameter and risk of cardiovascular events and mortality. A prospective multicenter cohort study.
There are conflicting evidence on the association between atrial fibrillation (AF) pattern, such as persistent/permanent (Pers/Perm) and paroxysmal (PAF) AF and risk of ischemic events. We investigated if left atrial diameter (LAd) may affect the risk of cardiovascular outcomes according to AF pattern. ⋯ LAd is a simple parameter that can be obtained in virtually all AF patients and can provide prognostic information on the risk of CVEs, MACE and CV death regardless of AF pattern.
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Int. J. Clin. Pract. · Mar 2021
Multicenter StudyMechanisms and grading of nocturia: Results from a multicenter prospective study.
To identify the pathophysiological mechanisms of nocturia and the correlation of these mechanisms with nocturia severity. ⋯ Nocturia mechanisms may vary between mild and moderate to severe nocturia groups according to the present study. Nocturia grading with identification of subtypes may help for better standardisation of the diagnostic and treatment approaches as well as for the design of future clinical trials.
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Int. J. Clin. Pract. · Mar 2021
Multicenter StudyPrevention of long-lasting atrial fibrillation through antitachycardia pacing in DDDR pacemakers.
The MINERVA trial showed that in pacemaker patients with atrial fibrillation (AF) history, DDDRP pacing combining three algorithms - (a) atrial antitachycardia pacing with Reactive ATP enabled, (b) atrial preventive pacing and (c) managed ventricular pacing (MVP)-may effectively delay progression to persistent/permanent AF compared with standard DDDR pacing. We performed a comparative non-randomised evaluation to evaluate if Reactive ATP can be the main driver of persistent/permanent AF reduction independently on preventive pacing. ⋯ In a real-world population of dual-chamber pacemaker patients with AF history, the use of Reactive ATP is associated with a low incidence of persistent AF, highlighting that the positive results of the MINERVA trial were related to the effectiveness of Reactive ATP rather than to preventive pacing.
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Int. J. Clin. Pract. · Mar 2021
Multicenter Study Observational StudyGender-related clinical and management differences in patients with chronic heart failure with reduced ejection fraction.
Gender-related differences have been described in the clinical characteristics and management of patients with chronic heart failure with reduced ejection fraction (HFrEF). However, published data are conflictive in this regard. ⋯ In summary, although management seemed to be equivalent between genders, women tended to present with more symptoms, require hospitalisation more frequently and have different comorbidities than men. These results highlight the importance of gender-related differences in HFrEF and call for further research to clarify the causes of these disparities. Gender-specific recommendations should be included in future guidelines in HFrEF.