International journal of clinical practice
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Int. J. Clin. Pract. · May 2021
Meta AnalysisActive and passive immunization with myelin basic protein as a window for treatment of spinal cord injury; A systematic review and meta-analysis.
Spinal cord injury (SCI), as a dangerous central nervous system damage, continues to threaten communities by imposing various disabilities and costs. These damages may be prevented by adjusting the immune system response using Myelin Basic Protein (MBP) immunization. As a result, the current study is designed to review and analyze the evidence on this subject. ⋯ The results of the present study demonstrated that immunization with MBP, especially in its active form, could significantly improve motor function following SCI. However, the safety of this method is still in debate. Therefore, it is recommended for future research to focus on the investigation of its safety in animal studies, before conducting human clinical trials.
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Int. J. Clin. Pract. · May 2021
Meta AnalysisEfficacy and safety of OM-85 in pediatric recurrent respiratory tract infections which could have a possible protective effect in COVID-19 pandemic: A meta-analysis.
The OM-85 (Broncho-Vaxom) consumption has drawn considerable attention in the prevention of recurrent respiratory tract infections. However, it has been reported that the relationship between OM-85 consumption and recurrent respiratory tract infections is variable. This meta-analysis was performed to evaluate this relationship. ⋯ The impact of OM-85 consumption on recurrent respiratory tract infections may have a great effect as a tool to improve subjects' immunity against recurrent respiratory tract infections, which could be helpful in crucial situations, eg, COVID-19 pandemic. OM-85 non-consumers had an independent risk relationship with recurrent respiratory tract infections. This relationship forces us to recommend OM-85 consumption with those with a high risk of recurrent respiratory tract infections to avoid any possible complications.
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Int. J. Clin. Pract. · May 2021
Meta AnalysisDexmedetomidine versus fentanyl as adjuvants to ropivacaine for epidural anesthesia：a systematic review and meta-analysis.
Several randomized controlled trials (RCTs) have evaluated the use of dexmedetomidine versus fentanyl as adjuvants to ropivacaine for epidural anaesthesia, yet the results are conflicting. We aimed to conduct this meta-analysis to assess the effects and safety of dexmedetomidine and fentanyl as adjuvants to ropivacaine for epidural anaesthesia. ⋯ Dexmedetomidine is better than fentanyl as adjuvant to ropivacaine for epidural anaesthesia with better effects and less adverse events.
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Int. J. Clin. Pract. · May 2021
Review Meta AnalysisComparison of the Effect of Educational and Self-Management Interventions on Adherence to Treatment in Hemodialysis Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Adherence to fluid intake, diet, and drug management is very important in hemodialysis patients. Educational and self-management interventions are frequently used to improve adherence to treatment in hemodialysis patients. ⋯ The analysis shows that educational and self-management interventions had a beneficial effect on adherence to fluid intake, diet, and drug management and no difference between these interventions. Therefore, these interventions can be used by healthcare professionals. It is also recommended that these interventions be well defined and transferable to routine clinical practice.
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Int. J. Clin. Pract. · May 2021
Meta AnalysisEfficacy and Safety of Mirogabalin Treatment in Patients with Diabetic Peripheral Neuropathic Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
We aimed to perform a systematic review and meta-analysis to examine the efficacy and safety of mirogabalin in patients with diabetic peripheral neuropathic pain (DPNP). ⋯ Our systematic review and meta-analysis revealed that in patients with DPNP, mirogabalin treatment was superior to placebo and pregabalin in decreasing the ADPS over time. Besides, mirogabalin was largely safe and associated with some adverse events that could be managed conservatively.