International journal of clinical practice
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Int. J. Clin. Pract. · Aug 2021
Multicenter StudyThe Effect of Risk Factors on Surgical and Oncological Results in High - Risk Prostate Cancer: A Multicenter Study of the Urooncology Society, Turkey.
To evaluate the effect of risk factors and selected surgical methods on operative and oncological results of patients undergoing radical prostatectomy (RP) with high-risk prostate cancer (HRPC). ⋯ RP alone is an effective treatment in the majority of patients with HRPC and PLND did not affect the progression rates after RP. According to the number of pre-operative high-risk features, as the number of risk factors increases, there is a need for additional treatment.
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Int. J. Clin. Pract. · Aug 2021
Consensus-Based Recommendations for Titrating Cannabinoids and Tapering Opioids for Chronic Pain Control.
Opioid misuse and overuse have contributed to a widespread overdose crisis and many patients and physicians are considering medical cannabis to support opioid tapering and chronic pain control. Using a five-step modified Delphi process, we aimed to develop consensus-based recommendations on: 1) when and how to safely initiate and titrate cannabinoids in the presence of opioids, 2) when and how to safely taper opioids in the presence of cannabinoids and 3) how to monitor patients and evaluate outcomes when treating with opioids and cannabinoids. ⋯ This five-stage modified Delphi process led to the development of consensus-based recommendations surrounding the safe introduction and titration of cannabinoids in concert with tapering opioids.
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Int. J. Clin. Pract. · Aug 2021
Effectiveness of ozone therapy in addition to conventional treatment on mortality in patients with COVID-19.
In this study, we aimed to investigate the effectiveness of ozone therapy, which is one of the integrative medicine applications that has been used safely for many years, on the prevalence of mortality in patients receiving COVID-19 treatment. ⋯ In this study, the findings suggested that the administration of ozone therapy along with the conventional medical treatment in patients hospitalised for COVID-19 could reduce mortality.
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Int. J. Clin. Pract. · Aug 2021
Urination behaviors of senior citizens in five Chinese cities: results of a cross-sectional survey.
To investigate the urination behaviours of senior citizens in China. ⋯ Unhealthy urination behaviours, including urinating at night and holding back urine, were common among senior citizens. This result can provide information for the prevention and control of urinary system diseases.
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Int. J. Clin. Pract. · Aug 2021
Deprescribing in older patients by early-career general practitioners: prevalence and associations.
Deprescribing is the health-professional-supervised process of withdrawal of an inappropriate medication to manage polypharmacy and improve patient outcomes. Given the harms of polypharmacy and associated inappropriate medicines, practitioners, especially general practitioners (GPs), are encouraged to take a proactive role in deprescribing in older patients. While trial evidence for benefits of deprescribing is accumulating, there is currently little epidemiologic evidence of clinicians' (including GPs') deprescribing behaviours. We aimed to establish the prevalence and explore associations of deprescribing of inappropriate medicines by early-career GPs. ⋯ These findings will have important implications for the education of GPs in deprescribing as a clinical skill.