International journal of clinical practice
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Int. J. Clin. Pract. · Nov 2021
Meta AnalysisEffect of Orlistat on serum Uric acid level in adults: A systematic review and meta-analysis of randomized controlled trials.
Hyperuricemia increases the risk of gout and cardiovascular diseases. Obesity increases the risk of hyperuricemia while weight loss (>5 kg) has been reported to decrease urate. The effects of orlistat on serum uric acid (SUA) are still controversial. The aim of this meta-analysis was to evaluate the influence of orlistat on SUA levels in adults. ⋯ We found a significant reduction in SUA following orlistat therapy in adults.
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Int. J. Clin. Pract. · Nov 2021
Meta AnalysisPrognostic value of Neutrophil-to-lymphocyte ratio in COVID-19 patients: A systematic review and meta-analysis.
Neutrophil-to-lymphocyte ratio (NLR) is an accessible and widely used biomarker. NLR may be used as an early marker of poor prognosis in patients with COVID-19. ⋯ Higher values of NLR were associated with severity and all-cause mortality in hospitalised COVID-19 patients.
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Int. J. Clin. Pract. · Nov 2021
Meta AnalysisInfarct volume and outcome of cerebral ischemia, a systematic review, and meta-analysis.
Multiple studies have evaluated the accuracy of infarct volume (IV) as a predictor of outcome in patients with ischaemic stroke; however, no study has systematically reviewed the results of these studies. ⋯ The results of the meta-analysis revealed a significant association between IV and unfavourable functional outcomes in patients with ischaemic stroke.
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Palindromic rheumatism (PR) characterised by self-resolving attacks of arthritis and peri-arthritis that may progress to other autoimmune connective tissue diseases (CTDs). The aim of this systematic review was to analyse the effectiveness of different treatments on PR. ⋯ Although case series and retrospective studies showed that DMARDs can control attacks of the disease, our review suggests that randomised clinical trials and prospective studies with adequate sample size are needed to prove that DMARDs can prevent progression of PR to autoimmune CTDs and which DMARDs are preferred for the treatment of PR.
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Int. J. Clin. Pract. · Nov 2021
Meta AnalysisThe Effect of Grape Seed Extract Supplementation on Oxidative Stress and Inflammation ─ A Systematic Review and Meta-Analysis of Controlled Trials.
Grape seed extract (GSE) seems to have antioxidant and anti-inflammatory properties due to its high polyphenolic content. Nevertheless, the scientific literature in this field is controversial and inconclusive. Therefore, we aimed to conduct a systematic review and meta-analysis of controlled trials to evaluate the effect of supplementation with GSE on biomarkers of oxidative stress and inflammation. ⋯ It appears that GSE supplementation can remarkably modulate the body's redox system, particularly through the inhibition of lipid peroxidation, but has neutral or mildly beneficial effects on inflammatory responses.