European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
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Eur. J. Paediatr. Neurol. · Mar 2019
Multicenter Study Comparative StudyFunctional outcome after traumatic cervical spinal cord injury is superior in adolescents compared to adults.
Determining differences in neurological and functional outcome between adolescents and adults after acute traumatic spinal cord injury (SCI). ⋯ Neurological outcome after traumatic cervical SCI is not superior in adolescents compared to adults in this cohort. Significantly higher SCIM scores indicate more functional gain for the adolescent patients after traumatic cervical SCI. Juvenile age appears to be an independent predictor for a better functional outcome.
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Eur. J. Paediatr. Neurol. · May 2017
Multicenter StudySurvey on treatments for primary headaches in 13 specialized juvenile Headache Centers: The first multicenter Italian study.
The purpose of this retrospective multicenter study was to evaluate the use and the self-perceived efficacy and tolerability of pharmacological and non-pharmacological treatments in children and adolescents with primary headaches. ⋯ Non-steroidal anti-inflammatory drugs, especially ibuprofen, should be preferred to acetaminophen for acute attacks of migraine or tension-type headache, because they were usually more effective and well tolerated. Triptans could be used more frequently as first or almost second choice for treating migraine attack in adolescents. Non-pharmacological preventive treatments are recommended by some pediatric guidelines as first-line interventions for primary headaches and their use should be implemented in clinical practice. Prospective multicenter studies based on larger series are warranted to better understand the best treatment strategies for young people with primary headaches.
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Eur. J. Paediatr. Neurol. · Sep 2014
Multicenter StudyLacosamide in children with refractory status epilepticus. A multicenter Italian experience.
Status epilepticus (SE) is considered a life-threatening medical emergency. First-line treatment with antiepileptic drugs (AEDs) consists of intravenous benzodiazepines followed by phenytoin. SE is considered refractory (RSE) when unresponsive to standard doses of the first two AEDs. Scarce evidence is available to support specific guidelines for the management of RSE in either adults or children. This study aimed to assess the efficacy and tolerability of intravenous (iv) lacosamide (LCM) in children affected by RSE. ⋯ LCM might be an effective and well-tolerated AED in children with RSE.
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Eur. J. Paediatr. Neurol. · Jan 2014
Multicenter StudyEfficacy and safety of lacosamide in infants and young children with refractory focal epilepsy.
Lacosamide is effective and well-tolerated antiepileptic drug (AED) in both children and adults. ⋯ We conclude that lacosamide is an effective and a well-tolerated antiepileptic drug in an etiologically wide range of focal seizures. Therefore, lacosamide might represent a possible therapeutic option in infants and young children affected by uncontrolled focal epilepsy.
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Eur. J. Paediatr. Neurol. · Jul 2008
Multicenter Study Clinical TrialAdd-on levetiracetam in children and adolescents with refractory epilepsy: results of an open-label multi-centre study.
To study the efficacy and tolerability of add-on levetiracetam in children and adolescents with refractory epilepsy. ⋯ Levetiracetam proved to be an effective and well-tolerated add-on treatment in this group of children with refractory epilepsy.