Pulmonary pharmacology & therapeutics
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Pulm Pharmacol Ther · Oct 2016
Randomized Controlled TrialEfficacy of tranexamic acid in haemoptysis: A randomized, controlled pilot study.
Haemoptysis is a life threatening condition irrespective of aetiology. Tranexamic acid (TA), a potent anti-fibrinolytic agent, has been shown to control bleeding, decrease transfusion requirement in knee & hip arthroplasty, coronary artery bypass grafting and heavy menstrual bleeding. TA also has mortality benefit in bleeding from surgical and trauma patients. But the studies, regarding efficacy and safety of TA in controlling haemoptysis are conflicting. ⋯ TA decreases severity of haemoptysis and can be used as a bridging therapy in acute haemoptysis before definitive intervention can be under taken.
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Pulm Pharmacol Ther · Oct 2016
Randomized Controlled TrialAntitussive effect of carcainium chloride in patients with chronic cough and idiopathic interstitial pneumonias: A pilot study.
Cough is a common presenting symptom in patients with idiopathic interstitial pneumonia (IIP); it is often disabling, and lacks effective treatment. Studies in animals suggest that carcainium chloride, a quaternary derivative of the local anesthetic lidocaine, is able to inhibit experimentally induced cough by a mechanism of action distinct from that of lidocaine. ⋯ The results of this exploratory study indicate that nebulised VRP700 improved cough and quality of life in hospitalised IIP patients with no significant side effects. A larger trial is warranted to assess these promising results.