European journal of pain : EJP
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This updated systematic review evaluated the efficacy and safety of opioids compared with placebo for chronic osteoarthritis pain. ⋯ Within the context of randomized controlled trials (4-24 weeks), opioids provided no clinically relevant pain relief and no clinically relevant reduction in disability compared with placebo in chronic osteoarthritis pain (hip, knee). Number needed to treat for an additional dropout due to side effects was 5 (95% confidence interval 4-7). Two studies found no signals of abuse and addiction. The frequency of serious adverse events including deaths did not differ from placebo.
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Review Meta Analysis
Prognostic factors for pain and functional disability in children and adolescents with persisting pain: a systematic review and meta-analysis.
The aim of this study was to investigate prognostic factors for pain and functional disability in children and/or adolescents with persisting pain. ⋯ Prognostic factors from across the biopsychosocial spectrum are important to consider in paediatric pain clinical practice. However, most prognostic factors that experts have previously agreed upon have not been assessed in prospective cohort studies to date. The findings may help with prioritising data to collect during clinical assessments of children presenting with pain, in the context of pain and functional disability outcomes.