The British journal of surgery
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Randomized Controlled Trial Clinical Trial
Randomized clinical trial of multimodal optimization of surgical care in patients undergoing major colonic resection.
The aim of this trial was to compare multimodal optimization with conventional perioperative management in a consecutive series of patients undergoing a wide range of colorectal procedures. ⋯ Optimization is safe and results in a significant reduction in postoperative stay along with other improved endpoints. This cannot be directly attributed to improvement in any single outcome measure or to the use of epidural analgesia. Improvements are more likely to be multifactorial and may relate to an earlier return of gut function.