The British journal of surgery
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Randomized Controlled Trial Multicenter Study Comparative Study
Five-year follow-up of the Medical Research Council CLASICC trial of laparoscopically assisted versus open surgery for colorectal cancer.
The UK Medical Research Council CLASICC trial assessed the safety and efficacy of laparoscopically assisted surgery in comparison with open surgery for colorectal cancer. The results of the 5-year follow-up analysis are presented. ⋯ ISRCTN74883561 (http://www.controlled-trials.com).
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Review Meta Analysis Comparative Study
Systematic review and meta-analysis of preoperative antisepsis with chlorhexidine versus povidone-iodine in clean-contaminated surgery.
Surgical-site infection increases morbidity, mortality and financial burden. The preferred topical antiseptic agent (chlorhexidine or povidone-iodine) for preoperative skin cleansing is unclear. ⋯ Chlorhexidine should be used preferentially for preoperative antisepsis in clean-contaminated surgery.
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Non-operative management (NOM) of blunt splenic injuries is nowadays considered the standard treatment. The present study identified selection criteria for primary operative management (OM) and planned NOM. ⋯ NOM of blunt splenic injuries has a low failure rate. Advanced age is independently associated with an increased failure rate.
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Randomized Controlled Trial
Randomized clinical trial of gut-specific nutrients in critically ill surgical patients.
Inadequate gut function is common and may adversely affect prognosis. However, it is difficult to measure and treatment options are limited. This study evaluated whether gut-specific nutrients (GSNs) could stimulate the return of gut function in critically ill patients, and assessed what effect, if any, this would have on patient outcomes. ⋯ ISRCTN61157513 (http://www.controlled-trials.com).