The British journal of surgery
-
Review Meta Analysis
Meta-analysis of biomarkers predicting risk of malignant progression in Barrett's oesophagus.
Barrett's oesophagus is a precursor to the development of oesophageal adenocarcinoma. This study sought to clarify the role of genetic, chromosomal and proliferation biomarkers that have been the subjects of multiple studies through meta-analysis. ⋯ Loss and mutation of p53, and raised level of Ki-67 predicted malignant progression in Barrett's oesophagus.
-
Anastomotic leakage (AL) following colorectal surgery can be difficult to diagnose owing to varying clinical presentations. This systematic review aimed to assess biomarkers as potential diagnostic tests for preclinical detection of AL. ⋯ Peritoneal drain fluid and systemic biomarkers are poor predictors of AL after colorectal surgery. Combinations of these biomarkers showed improvement in predictive accuracy.
-
The evidence for treatment decision-making in emergency general surgery has not been summarized previously. The aim of this overview was to review the quantity and quality of systematic review evidence for the most common emergency surgical conditions. ⋯ This overview of reviews highlights the need for more and better research in this field.
-
The evidence for treatment decision-making in emergency general surgery has not been summarized previously. The aim of this overview was to review the quantity and quality of systematic review evidence for the most common emergency surgical conditions. ⋯ This overview of reviews highlights the need for more and better research in this field.