The British journal of surgery
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Randomized Controlled Trial Multicenter Study
Antibiotic prophylaxis for acute cholecystectomy: PEANUTS II multicentre randomized non-inferiority clinical trial.
Guidelines recommending antibiotic prophylaxis at emergency cholecystectomy for cholecystitis were based on low-quality evidence. The aim of this trial was to demonstrate that omitting antibiotics is not inferior to their prophylactic use. ⋯ Omitting antibiotic prophylaxis is not recommended.
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Randomized Controlled Trial Multicenter Study
Pancreatoduodenectomy with or without prophylactic falciform ligament wrap around the hepatic artery for prevention of postpancreatectomy haemorrhage: a randomized clinical trial (PANDA trial).
Postpancreatectomy haemorrhage (PPH) is a rare but potentially fatal complication after pancreatoduodenectomy. Preventive strategies are lacking with scarce data for support. The aim of this study was to investigate whether a prophylactic falciform ligament wrap around the hepatic and gastroduodenal artery can prevent PPH from these vessels. ⋯ NCT02588066 (http://www.clinicaltrials.gov).
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Randomized Controlled Trial Multicenter Study
A randomized clinical trial comparing early patient-reported pain after open anterior mesh repair versus totally extraperitoneal repair of inguinal hernia.
This was a prospective, multicentre, non-blinded, randomized clinical trial involving two parallel groups of patients. ⋯ TEP inguinal hernia repair is associated with less early postoperative pain compared to the open glue mesh fixation technique.
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Randomized Controlled Trial Multicenter Study
Radiomics modelling in rectal cancer to predict disease-free survival: evaluation of different approaches.
Radiomics may be useful in rectal cancer management. The aim of this study was to assess and compare different radiomics approaches over qualitative evaluation to predict disease-free survival (DFS) in patients with locally advanced rectal cancer treated with neoadjuvant therapy. ⋯ Radiomics models can predict DFS in patients with locally advanced rectal cancer.
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Randomized Controlled Trial Comparative Study
A randomized controlled trial comparing the effect of three-dimensional simulation of aesthetic outcome from breast-conserving surgery with viewing photographs or standard care.
Over half of women with surgically managed breast cancer in the UK undergo breast-conserving treatment (BCT). While photographs are shown prior to reconstructive surgery or complex oncoplastic procedures, standard practice prior to breast conservation is to simply describe the likely aesthetic changes. Patients have expressed the desire for more personalized information about likely appearance after surgery. The hypothesis was that viewing a three-dimensional (3D) simulation improves patients' confidence in knowing their likely aesthetic outcome after surgery. ⋯ This RCT has demonstrated that women who viewed an individualized 3D simulation of likely aesthetic outcome for BCT were more confident going into surgery than those who received standard care or who were shown 2D photographs of other women. The impact on longer-term satisfaction with outcome remains to be determined.Registration number: NCT03250260 (http://www.clinicaltrials.gov).