Critical care : the official journal of the Critical Care Forum
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Multicenter Study Clinical Trial
Benefit profile of anticoagulant therapy in sepsis: a nationwide multicentre registry in Japan.
Little evidence supports anticoagulant therapy as effective adjuvant therapy to reduce mortality overall in sepsis. However, several studies suggest that anticoagulant therapy may reduce mortality in specific patients. This study aimed to identify a subset of patients with high benefit profiles for anticoagulant therapy against sepsis. ⋯ The analysis of this large database indicates anticoagulant therapy may be associated with a survival benefit in patients with sepsis-induced coagulopathy and/or very severe disease.