Critical care : the official journal of the Critical Care Forum
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Randomized Controlled Trial
Decreased cytokine production by mononuclear cells after severe gram-negative infections: early clinical signs and association with final outcome.
Failure of circulating monocytes for adequate cytokine production is a trait of sepsis-induced immunosuppression; however, its duration and association with final outcome are poorly understood. ⋯ Defective TNF-α production is a major trait of sepsis-induced immunosuppression. It is associated with significant risk for unfavourable outcome and persists until day 10. Cardiovascular failure on admission is predictive of defective TNF-α production during follow-up.