Critical care : the official journal of the Critical Care Forum
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Editorial Comment
Designing nutrition-based interventional trials for the future: addressing the known knowns.
The consistent decline in critical illness mortality has a significant effect on trial design, whereby either an improbable effect sizes or large number of patients are required. The signal-to-noise ratio is of particular interest for the critically ill. ⋯ However, a fundamental interaction is often not accounted for time. Working as a community to evolve trial design will be our challenge for nutrition interventions in the critically ill for the future.
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Abstract
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Abstract