Critical care : the official journal of the Critical Care Forum
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Review Meta Analysis
Prevention of ventilator-associated pneumonia by metal-coated endotracheal tubes: a meta-analysis.
This study aimed to evaluate whether endotracheal tubes (ETTs) with a metal coating reduce the incidence of ventilator-associated pneumonia (VAP) compared to uncoated ETTs. ⋯ https://www.crd.york.ac.uk/prospero/ , identifier CRD42024560618.
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Meta Analysis
Divergent effects of tumor necrosis factor (TNF) in sepsis: a meta-analysis of experimental studies.
Experimental studies in animals have yielded conflicting results on the role of Tumor Necrosis Factor (TNF) in sepsis and endotoxemia, with some reporting adaptive and others inappropriate effects. A meta-analysis of the available literature was performed to determine the factors explaining this discrepancy. ⋯ The role of TNF during infection varies depending on the experimental model used. Models that mimic clinical conditions, based on virulent bacteria that cause high mortality even at low inocula, demonstrated an adaptive role of TNF. Conversely, models based on LPS or low-pathogenic live bacteria, administered at doses well above physiological thresholds and combined with early antibiotic therapy, were associated with an inappropriate role.