Pediatric transplantation
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Pediatric transplantation · Sep 2014
Case ReportsCutaneous squamous cell carcinoma in two pediatric lung transplant patients on prolonged voriconazole treatment.
Oral voriconazole is commonly used for treatment and prophylaxis of invasive fungal disease post-LTx. Development of cutaneous SCC has been described in adult LTx recipients, although it is extremely rare in children. ⋯ Neither patient developed metastatic lesions nor had allograft dysfunction as a result of the SCC or the change in medical treatments. The effect of voriconazole on the development of malignant skin lesions is discussed and a recommendation on dermatologic surveillance, preventive measures against phototoxicity and early treatment of SCC are provided.