Neuromodulation : journal of the International Neuromodulation Society
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Complications associated with intrathecal pumps may be linked to the surgical procedure, the implanted device, or the medication itself. ⋯ Inadvertent injection into the subcutaneous pocket rather than the reservoir is rare but very dangerous as the drug cannot be retrieved and massive doses are involved. Signs and symptoms of systemic overdose with drugs commonly used in implanted drugs delivery system should be well known to ensure early diagnosis and treatment.
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In able-bodied participants, it is possible to induce a sense of perceptual embodiment in an artificial hand using a visual-tactile illusion. In amputee patients, electrical stimulation of sensory afferents using transcutaneous electrical nerve stimulation (TENS) has been shown to generate somatic sensations in an amputee's phantom limb(s). However, the effects of TENS on the perceptual embodiment of an artificial limb are not known. Our objective was to investigate the effects of TENS on the perceptual embodiment of an artificial limb in fully intact able-bodied participants. ⋯ Our findings provide initial evidence that TENS paresthesia can be projected into an artificial limb, and this can enhance the sense of perceptual embodiment of an artificial hand. Further exploratory studies involving an amputee population are warranted.
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Clinical Trial
Continuous versus intermittent spinal cord stimulation: an analysis of factors influencing clinical efficacy.
Spinal cord stimulation (SCS) has, for decades, been shown to be successful in a variety of chronic neuropathic pain syndromes. However, there is a paucity of reports in the literature comparing different stimulation patterns. The impact of different stimulation patterns upon outcome remains to be determined, as well as how the latter is influenced by the duration of the post-SCS pain-free interval. ⋯ Our data showed an equal effectiveness of SCS in the intermittent and in the continuous stimulation mode. The duration of the post-SCS pain-free interval may be predictive for the choice of the most effective individual stimulation pattern and deserves further investigation.
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Some patients with spasticity and pain in the extremities fail to respond to increases in the dose of intrathecally delivered baclofen. ⋯ We suggest that in patients who experience symptom aggravation at increased ITB doses, potential causative factors and ITB system malfunction should first be ruled out, and consideration should then be given to decreasing the ITB dose.
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Multicenter Study Clinical Trial
A prospective, open-label, multicenter study to assess the efficacy of spinal cord stimulation and identify patients who would benefit.
To identify patients likely to benefit from spinal cord stimulation (SCS). ⋯ SCS may improve pain management and QOL.