Neuromodulation : journal of the International Neuromodulation Society
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Multicenter Study Clinical Trial
Subthalamic deep brain stimulation with a new device in Parkinson's disease: an open-label trial.
We aimed to evaluate the safety and efficacy of subthalamic nucleus deep brain stimulation (STN-DBS) with a new stimulator (Beijing PINS Medical Co., Ltd, PNS 1101) in Parkinson's disease (PD). ⋯ STN-DBS with the PINS device significantly improved the symptoms of PD when compared with baseline in this trial. This new device may be recommended for the treatment of patients with advanced PD; however, a randomized, double-blinding trial will be required.
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Multicenter Study
Rate of complications among the recipients of intrathecal baclofen pump in Japan: a multicenter study.
To evaluate the incidence of complications of intrathecal baclofen (ITB) therapy for spasticity in Japan, where a unique training course and nationwide registration are required. ⋯ The requirement of taking of a training course before starting ITB seemed to reduce complications. Although there were surgery-related complications, the rate of complications in Japan appeared to be lower than those reported in larger series of ITB. However, whether the reported rates can be primarily ascribed to a mandatory training course requires further investigations.
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Multicenter Study
Rechargeable vs. nonrechargeable internal pulse generators in the management of dystonia.
To test if deep brain stimulation (DBS) treatment of dystonia was similar in patients before and after implantation of rechargeable internal pulse generators (IPGs). ⋯ Rechargeable IPGs should be the IPGs of choice for dystonic patients receiving DBS as IPGs offer similar treatment efficacy to nonrechargeable IPGs with advantages in terms of costs and reductions in reimplantation frequency.
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We retrospectively investigated the correlation between disease duration and the therapeutic effect of globus pallidus internus (GPi) stimulation in patients with primary cervical dystonia (CD). ⋯ Bilateral GPi-DBS is an effective long-term therapy in patients with CD. The delivery of GPi stimulation in the earlier course of CD may yield greater postoperative improvement.
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To investigate whether spinal cord stimulation (SCS) has a negative effect on static balance and gait, which is implicated by the increased incidence of falls leading to frequently occurring lead migrations. ⋯ The lack of group differences in normal gait and static balance cannot explain the increased incidence of falls. However, four subjects showed an effect of SCS on static balance. Further research to clarify why only a part of the subjects experienced balance problems is recommended and assessments of more demanding balance and gait tasks are desirable.